SARS-CoV-2 variants have evolved over time in recent years. demonstrating immune evasion of vaccine-induced neutralizing antibodies directed against the original S protein. Updated S-targeted vaccines provide a high level of protection against circulating variants of SARS-CoV-2. but this protection declines over time due to ongoing virus evolution. https://www.petsafewirelessfence.com/product-category/womens-footwear/