Vascular endothelial growth factor (VEGF). originally described as a factor with a regulatory role in vascular growth and development. it is also known for its direct effects on neuronal cells. The discovery in the past decade that transgenic mice expressing reduced levels of VEGF developed late-onset motoneuron pathology. https://www.roneverhart.com/Mesa-Boogie-Rectifier-4x12-Cabinet-Standard-Straight-p31703/